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Integrin-α9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis
Dysfunction of lymphatic valves underlies human lymphedema, yet the process of valve morphogenesis is poorly understood. Here, we show that during embryogenesis lymphatic valve leaflet formation is initiated by upregulation of integrin-α9 expression and deposition of its ligand, fibronectin-EIIIA (F...
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| 主要な著者: | , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2009
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2747264/ https://ncbi.nlm.nih.gov/pubmed/19686679 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2009.06.017 |
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