Integrin-α9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis

Dysfunction of lymphatic valves underlies human lymphedema, yet the process of valve morphogenesis is poorly understood. Here, we show that during embryogenesis lymphatic valve leaflet formation is initiated by upregulation of integrin-α9 expression and deposition of its ligand, fibronectin-EIIIA (F...

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Bibliografski detalji
Glavni autori: Bazigou, Eleni, Xie, Sherry, Chen, Chun, Weston, Anne, Miura, Naoyuki, Sorokin, Lydia, Adams, Ralf, Muro, Andrés F., Sheppard, Dean, Makinen, Taija
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2747264/
https://ncbi.nlm.nih.gov/pubmed/19686679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2009.06.017
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