Evolution of Enzymatic Activities in the Enolase Superfamily: Stereochemically Distinct Mechanisms in Two Families of cis,cis-Muconate Lactonizing Enzymes

The mechanistically diverse enolase superfamily is a paradigm for elucidating Nature’s strategies for divergent evolution of enzyme function. Each of the different reactions catalyzed by members of the superfamily is initiated by abstraction of the α-proton of a carboxylate substrate that is coordin...

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Autores principales: Sakai, Ayano, Fedorov, Alexander A., Fedorov, Elena V., Schnoes, Alexandra M., Glasner, Margaret E., Brown, Shoshana, Rutter, Marc E., Bain, Kevin, Chang, Shawn, Gheyi, Tarun, Sauder, J. Michael, Burley, Stephen K., Babbitt, Patricia C., Almo, Steven C., Gerlt, John A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2746992/
https://ncbi.nlm.nih.gov/pubmed/19220063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi802277h
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