Evolution of Enzymatic Activities in the Enolase Superfamily: Stereochemically Distinct Mechanisms in Two Families of cis,cis-Muconate Lactonizing Enzymes

The mechanistically diverse enolase superfamily is a paradigm for elucidating Nature’s strategies for divergent evolution of enzyme function. Each of the different reactions catalyzed by members of the superfamily is initiated by abstraction of the α-proton of a carboxylate substrate that is coordin...

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Autori principali: Sakai, Ayano, Fedorov, Alexander A., Fedorov, Elena V., Schnoes, Alexandra M., Glasner, Margaret E., Brown, Shoshana, Rutter, Marc E., Bain, Kevin, Chang, Shawn, Gheyi, Tarun, Sauder, J. Michael, Burley, Stephen K., Babbitt, Patricia C., Almo, Steven C., Gerlt, John A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2746992/
https://ncbi.nlm.nih.gov/pubmed/19220063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi802277h
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