Contribution of organic cation transporter 2 (OCT2) to cisplatin-induced nephrotoxicity

Cisplatin is one of the most widely used anticancer agents for the treatment of solid tumors. The clinical use of cisplatin is associated with dose-limiting nephrotoxicity, which occurs in one-third of patients despite intensive prophylactic measures. Organic cation transporter 2 (OCT2) has been imp...

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Hauptverfasser: Filipski, Kelly K., Mathijssen, Ron H., Mikkelsen, Torben S., Schinkel, Alfred H., Sparreboom, Alex
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2746866/
https://ncbi.nlm.nih.gov/pubmed/19625999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2009.139
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