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A Tetrahedral Transition State at the Active Sites of the 20S Proteasome is Coupled to Opening of the α-Ring Channel

Intrinsic conformational transitions contribute to the catalytic action of many enzymes. Here we use a single-molecule approach to demonstrate how such transitions are linked to the catalytic sites of the eukaryotic proteasome, an essential protease of the ubiquitin pathway. The active sites of the...

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Main Authors: Osmulski, Pawel A., Hochstrasser, Mark, Gaczynska, Maria
格式: Artigo
語言:Inglês
出版: 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2746003/
https://ncbi.nlm.nih.gov/pubmed/19679091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2009.06.011
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