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A Tetrahedral Transition State at the Active Sites of the 20S Proteasome is Coupled to Opening of the α-Ring Channel
Intrinsic conformational transitions contribute to the catalytic action of many enzymes. Here we use a single-molecule approach to demonstrate how such transitions are linked to the catalytic sites of the eukaryotic proteasome, an essential protease of the ubiquitin pathway. The active sites of the...
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| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2009
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2746003/ https://ncbi.nlm.nih.gov/pubmed/19679091 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2009.06.011 |
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