Platelet factor 4 regulates megakaryopoiesis through low-density lipoprotein receptor–related protein 1 (LRP1) on megakaryocytes

Platelet factor 4 (PF4) is a negative regulator of megakaryopoiesis, but its mechanism of action had not been addressed. Low-density lipoprotein (LDL) receptor–related protein-1 (LRP1) has been shown to mediate endothelial cell responses to PF4 and so we tested this receptor's importance in PF4...

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Autores principales: Lambert, Michele P., Wang, Yuhuan, Bdeir, Khalil H., Nguyen, Yvonne, Kowalska, M. Anna, Poncz, Mortimer
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2009
Materias:
Platelets and Thrombopoiesis
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2745847/
https://ncbi.nlm.nih.gov/pubmed/19605848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-04-216473
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