The Evolution of Proteins with Genetically Encoded “Chemical Warheads”

[Image: see text] We recently developed a phage-based system for the evolution of proteins in bacteria with expanded amino acid genetic codes. Here, we demonstrate that the unnatural amino acid p-boronophenylalanine (BF) confers a selective advantage in the evolution of glycan binding proteins. We s...

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Bibliografiske detaljer
Main Authors: Liu, Chang C., Mack, Antha V., Brustad, Eric M., Mills, Jeremy H., Groff, Dan, Smider, Vaughn V., Schultz, Peter G.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2745334/
https://ncbi.nlm.nih.gov/pubmed/19555063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja902985e
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