Protein evolution with an expanded genetic code

We have devised a phage display system in which an expanded genetic code is available for directed evolution. This system allows selection to yield proteins containing unnatural amino acids should such sequences functionally outperform ones containing only the 20 canonical amino acids. We have optim...

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Bibliographic Details
Main Authors:	Liu, Chang C., Mack, Antha V., Tsao, Meng-Lin, Mills, Jeremy H., Lee, Hyun Soo, Choe, Hyeryun, Farzan, Michael, Schultz, Peter G., Smider, Vaughn V.
Format:	Artigo
Language:	Inglês
Published:	National Academy of Sciences 2008
Subjects:	Biological Sciences
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2584696/ https://ncbi.nlm.nih.gov/pubmed/19004806 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0809543105
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Protein evolution with an expanded genetic code

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