Protein evolution with an expanded genetic code

We have devised a phage display system in which an expanded genetic code is available for directed evolution. This system allows selection to yield proteins containing unnatural amino acids should such sequences functionally outperform ones containing only the 20 canonical amino acids. We have optim...

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Detalhes bibliográficos
Main Authors: Liu, Chang C., Mack, Antha V., Tsao, Meng-Lin, Mills, Jeremy H., Lee, Hyun Soo, Choe, Hyeryun, Farzan, Michael, Schultz, Peter G., Smider, Vaughn V.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2584696/
https://ncbi.nlm.nih.gov/pubmed/19004806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0809543105
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