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Translocation of H-Ras and its implications in the development of diabetic retinopathy

H-Ras, a small molecular weight G- protein, undergoes post-translational modifications enabling its translocation from cytosol to the membrane. Hyperglycemia increases apoptosis of retinal capillary cells via activation of H-Ras, which can be ameliorated by farnesylation inhibitors. Our aim is to in...

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Bibliographic Details
Main Authors: Kowluru, Renu A., Kanwar, Mamta
Format: Artigo
Language:Inglês
Published: 2009
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2744948/
https://ncbi.nlm.nih.gov/pubmed/19607814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2009.07.038
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