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Role of Glyceraldehyde 3-Phosphate Dehydrogenase in the Development and Progression of Diabetic Retinopathy

OBJECTIVE—Mitochondrial superoxide levels are elevated in the retina in diabetes, and manganese superoxide dismutase overexpression prevents the development of retinopathy. Superoxide inhibits glyceraldehyde-3-phosphate dehydrogenase (GAPDH), which activates major pathways implicated in diabetic com...

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Detaylı Bibliyografya
Asıl Yazarlar: Kanwar, Mamta, Kowluru, Renu A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Diabetes Association 2009
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2606877/
https://ncbi.nlm.nih.gov/pubmed/18852331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-1025
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