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Translocation of H-Ras and its implications in the development of diabetic retinopathy
H-Ras, a small molecular weight G- protein, undergoes post-translational modifications enabling its translocation from cytosol to the membrane. Hyperglycemia increases apoptosis of retinal capillary cells via activation of H-Ras, which can be ameliorated by farnesylation inhibitors. Our aim is to in...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2744948/ https://ncbi.nlm.nih.gov/pubmed/19607814 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2009.07.038 |
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