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Guanine Nucleotide Exchange Factor-H1 Regulates Cell Migration via Localized Activation of RhoA at the Leading Edge

Cell migration involves the cooperative reorganization of the actin and microtubule cytoskeletons, as well as the turnover of cell–substrate adhesions, under the control of Rho family GTPases. RhoA is activated at the leading edge of motile cells by unknown mechanisms to control actin stress fiber a...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Nalbant, Perihan, Chang, Yuan-Chen, Birkenfeld, Jörg, Chang, Zee-Fen, Bokoch, Gary M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Cell Biology 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2743625/
https://ncbi.nlm.nih.gov/pubmed/19625450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E09-01-0041
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