PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility

Integrin binding to matrix proteins such as fibronectin (FN) leads to formation of focal adhesion (FA) cellular contact sites that regulate migration. RhoA GTPases facilitate FA formation, yet FA-associated RhoA-specific guanine nucleotide exchange factors (GEFs) remain unknown. Here, we show that p...

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Autors principals: Lim, Yangmi, Lim, Ssang-Taek, Tomar, Alok, Gardel, Margaret, Bernard-Trifilo, Joie A., Chen, Xiao Lei, Uryu, Sean A., Canete-Soler, Rafaela, Zhai, Jinbin, Lin, Hong, Schlaepfer, William W., Nalbant, Perihan, Bokoch, Gary, Ilic, Dusko, Waterman-Storer, Clare, Schlaepfer, David D.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2008
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2213606/
https://ncbi.nlm.nih.gov/pubmed/18195107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200708194
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