An Efficient Chemical Approach to Bispecific Antibodies and Antibodies of High Valency

Irreversible chemical programming of monoclonal aldolase antibody (mAb) 38C2 has been accomplished with β-lactam equipped mono- and bifunctional targeting modules, including a cyclic-RGD peptide linked to either the peptide (D-Lys6)-LHRH or another cyclic RGD unit and a small-molecule integrin inhib...

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Main Authors: Gavrilyuk, Julia I., Wuellner, Ulrich, Salahuddin, Syed, Goswami, Rajib K., Sinha, Subhash C., Barbas, Carlos F.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2743550/
https://ncbi.nlm.nih.gov/pubmed/19497743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.05.047
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