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An Efficient Chemical Approach to Bispecific Antibodies and Antibodies of High Valency
Irreversible chemical programming of monoclonal aldolase antibody (mAb) 38C2 has been accomplished with β-lactam equipped mono- and bifunctional targeting modules, including a cyclic-RGD peptide linked to either the peptide (D-Lys6)-LHRH or another cyclic RGD unit and a small-molecule integrin inhib...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2743550/ https://ncbi.nlm.nih.gov/pubmed/19497743 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.05.047 |
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