Enzymatic removal of mannose moieties can increase the immune response to HIV-1 gp120 in vivo

The Env glycoproteins gp120 and gp41 are used in humoral immunity-based vaccines against human immunodeficiency virus (HIV-1) infection. One among many obstacles to such a vaccine is the structural defenses of Env glycoproteins that limit their immunogenicity. For example, gp120 mannose residues can...

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Main Authors: Banerjee, Kaustuv, Andjelic, Sofija, Klasse, Per Johan, Kang, Yun, Sanders, Rogier W., Michael, Elizabeth, Durso, Robert J., Ketas, Thomas J., Olson, William C., Moore, John P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2743082/
https://ncbi.nlm.nih.gov/pubmed/19410272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2009.04.001
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