Translation attenuation through eIF2α phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells

Accumulation of unfolded protein within the endoplasmic reticulum (ER) lumen attenuates mRNA translation through activation of the protein kinase PERK and subsequent phosphorylation of eukaryotic initiation factor 2 on Ser51 of the alpha subunit (eIF2α). Genetic disruption of the PERK/eIF2α pathway...

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Main Authors: Back, Sung Hoon, Scheuner, Donalyn, Han, JaeSeok, Song, Benbo, Ribick, Mark, Wang, Junying, Gildersleeve, Robert D., Pennathur, Subramaniam, Kaufman, Randal J.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2742645/
https://ncbi.nlm.nih.gov/pubmed/19583950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2009.06.002
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