Antioxidants Complement the Requirement for Protein Chaperone Function to Maintain β-Cell Function and Glucose Homeostasis

Proinsulin misfolding in the endoplasmic reticulum (ER) initiates a cell death response, although the mechanism(s) remains unknown. To provide insight into how protein misfolding may cause β-cell failure, we analyzed mice with the deletion of P58(IPK)/DnajC3, an ER luminal co-chaperone. P58(IPK−/−)...

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Bibliographic Details
Published in:Diabetes
Main Authors: Han, Jaeseok, Song, Benbo, Kim, Jiun, Kodali, Vamsi K., Pottekat, Anita, Wang, Miao, Hassler, Justin, Wang, Shiyu, Pennathur, Subramaniam, Back, Sung Hoon, Katze, Michael G., Kaufman, Randal J.
Format: Artigo
Language:Inglês
Published: American Diabetes Association 2015
Subjects:
Islet Studies
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4512214/
https://ncbi.nlm.nih.gov/pubmed/25795214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db14-1357
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