IRE1α -XBP1s Induces PDI Expression to Increase MTP Activity for Hepatic VLDL Assembly and Lipid Homeostasis

The unfolded protein response (UPR) is a signaling pathway required to maintain endoplasmic reticulum (ER) homeostasis and hepatic lipid metabolism. Here, we identify an essential role for the inositol-requiring transmembrane kinase/endoribonuclease 1α (IRE1α)-X-box binding protein 1 (XBP1) arm of t...

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Main Authors: Wang, Shiyu, Chen, Zhouji, Lam, Vivian, Han, Jaeseok, Hassler, Justin, Finck, Brian N., Davidson, Nicholas O., Kaufman, Randal J.
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3569089/
https://ncbi.nlm.nih.gov/pubmed/23040069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2012.09.003
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