Φορτώνει......
Translation attenuation through eIF2α phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells
Accumulation of unfolded protein within the endoplasmic reticulum (ER) lumen attenuates mRNA translation through activation of the protein kinase PERK and subsequent phosphorylation of eukaryotic initiation factor 2 on Ser51 of the alpha subunit (eIF2α). Genetic disruption of the PERK/eIF2α pathway...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2009
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2742645/ https://ncbi.nlm.nih.gov/pubmed/19583950 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2009.06.002 |
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