FRAGILE X MENTAL RETARDATION PROTEIN REPLACEMENT RESTORES HIPPOCAMPAL SYNAPTIC FUNCTION IN A MOUSE MODEL OF FRAGILE X SYNDROME

Fragile X Syndrome (FXS) is caused by a mutation that silences the Fragile X Mental Retardation gene (FMR1) which encodes the Fragile X Mental Retardation Protein (FMRP). To determine if FMRP replacement can rescue phenotypic deficits in an fmr1 knockout (KO) mouse model of FXS, we constructed an Ad...

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Huvudupphovsmän: Zeier, Zane, Kumar, Ashok, Bodhinathan, Karthik, Feller, Joyce A., Foster, Thomas C., Bloom, David C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2741536/
https://ncbi.nlm.nih.gov/pubmed/19571888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2009.83
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