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The Immunoregulatory Enzyme IDO Paradoxically Drives B Cell-Mediated Autoimmunity

Rheumatoid arthritis (RA) is a chronic and debilitating inflammatory autoimmune disease of unknown etiology. As with a variety of autoimmune disorders, evidence of elevated tryptophan catabolism has been detected in RA patients, indicative of activation of the immunomodulatory enzyme indoleamine 2,3...

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Detalhes bibliográficos
Main Authors: Scott, Grant N., DuHadaway, James, Pigott, Elizabeth, Ridge, Natalie, Prendergast, George C., Muller, Alexander J., Mandik-Nayak, Laura
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2741092/
https://ncbi.nlm.nih.gov/pubmed/19494274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0804328
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