Differential Roles of IDO1 and IDO2 in T and B Cell Inflammatory Immune Responses

Indoleamine-2,3-dioxygenase (IDO)1 and IDO2 are two closely related tryptophan catabolizing enzymes encoded by linked genes. The IDO pathway is also immunomodulatory, with IDO1 well-characterized as a mediator of tumor immune evasion. Due to its homology with IDO1, IDO2 has been proposed to have a s...

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Main Authors: Lauren M. F. Merlo, James B. DuHadaway, James D. Montgomery, Wei-Dan Peng, Peter J. Murray, George C. Prendergast, Andrew J. Caton, Alexander J. Muller, Laura Mandik-Nayak
פורמט: Artigo
שפה:Inglês
יצא לאור: Frontiers Media S.A. 2020-08-01
סדרה:Frontiers in Immunology
נושאים:
experimental arthritis
influenza
immunization
B cells
murine model
גישה מקוונת:https://www.frontiersin.org/article/10.3389/fimmu.2020.01861/full
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