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The Flexibility of a Distant Loop Modulates Active-Site Motion and Product Release in Ribonuclease A

The role of the flexible loop 1 in protein conformational motion and the dissociation of enzymatic product from Ribonuclease A (RNase A) was investigated by creation of a chimeric enzyme in which a six residue loop 1 from the RNase A homolog, eosinophil cationic protein (ECP) replaced the twelve res...

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書誌詳細
主要な著者: Doucet, Nicolas, Watt, Eric D., Loria, J. Patrick
フォーマット: Artigo
言語:Inglês
出版事項: 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2741010/
https://ncbi.nlm.nih.gov/pubmed/19588901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi900830g
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