Rapid Solid-Phase Extraction Method to Quantify [(11)C]-Verapamil, and its [(11)C]-Metabolites, in Human and Macaque Plasma

INTRODUCTION: P-glycoprotein (P-gp), an efflux transporter, is a significant barrier to drug entry into the brain and the fetus. The Positron Emmison Topography (PET) ligand, [(11)C]-verapamil, has been used to measure in vivo P-gp activity at various tissue-blood barriers of humans and animals. Sin...

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Autores principales: Unadkat, JD., Chung, F., Sasongko, L., Whittington, D., Eyal, S., Mankoff, D., Collier, AC., Muzi, M., Link, J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2740738/
https://ncbi.nlm.nih.gov/pubmed/19026953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nucmedbio.2008.08.001
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