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Characterization of the kinase activity of a WNK4 protein complex

Mutations in WNK4 protein kinase cause pseudohypoaldosteronism type II (PHAII), a genetic disorder that is characterized by renal NaCl and K(+) retention leading to hypertension and hyperkalemia. Consistent with this, WNK4 is known to regulate several renal tubule transporters, including the NaCl co...

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Detalhes bibliográficos
Main Authors: Ahlstrom, Robert, Yu, Alan S. L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2739714/
https://ncbi.nlm.nih.gov/pubmed/19587141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00358.2009
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