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α-Latrotoxin Stimulates a Novel Pathway of Ca(2+)-Dependent Synaptic Exocytosis Independent of the Classical Synaptic Fusion Machinery

α-Latrotoxin induces neurotransmitter release by stimulating synaptic vesicle exocytosis via two mechanisms: (1) A Ca(2+)-dependent mechanism with neurexins as receptors, in which α-latrotoxin acts like a Ca(2+) ionophore, and (2) a Ca(2+)-independent mechanism with CIRL/latrophilins as receptors, i...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Deák, Ferenc, Liu, Xinran, Khvotchev, Mikhail, Li, Gang, Kavalali, Ege T., Sugita, Shuzo, Südhof, Thomas C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2739239/
https://ncbi.nlm.nih.gov/pubmed/19587270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0898-09.2009
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