alpha-latrotoxin action probed with recombinant toxin: receptors recruit alpha-latrotoxin but do not transduce an exocytotic signal.

alpha-Latrotoxin stimulates neurotransmitter release probably by binding to two receptors, CIRL/latrophilin 1 (CL1) and neurexin Ialpha. We have now produced recombinant alpha-latrotoxin (LtxWT) that is as active as native alpha-latrotoxin in triggering synaptic release of glutamate, GABA and norepi...

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Detalhes bibliográficos
Main Authors: Ichtchenko, K, Khvotchev, M, Kiyatkin, N, Simpson, L, Sugita, S, Südhof, T C
Formato: Artigo
Idioma:Inglês
Publicado em: 1998
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1170945/
https://ncbi.nlm.nih.gov/pubmed/9799228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.21.6188
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