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α-latrotoxin triggers transmitter release via direct insertion into the presynaptic plasma membrane

α-latrotoxin, a component of black widow spider venom, binds to presynaptic nerve terminals and stimulates massive neurotransmitter release. Previous studies have demonstrated that α-latrotoxin first binds to two high-affinity receptors on nerve terminals, neurexins and CLs (CIRLs and latrophilins),...

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Detalhes bibliográficos
Main Authors: Khvotchev, Mikhail, Südhof, Thomas C.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC313948/
https://ncbi.nlm.nih.gov/pubmed/10880438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.13.3250
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