BCR-ABL promotes the frequency of mutagenic single-strand annealing DNA repair

Intracellular oxidative stress in cells transformed by the BCR-ABL oncogene is associated with increased DNA double-strand breaks. Imprecise repair of these breaks can result in the accumulation of mutations, leading to therapy-related drug resistance and disease progression. Using several BCR-ABL m...

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Main Authors: Fernandes, Margret S., Reddy, Mamatha M., Gonneville, Jeffrey R., DeRoo, Scott C., Podar, Klaus, Griffin, James D., Weinstock, David M., Sattler, Martin
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2009
Fag:
Myeloid Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2738569/
https://ncbi.nlm.nih.gov/pubmed/19571320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-07-172148
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