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BCR-ABL promotes the frequency of mutagenic single-strand annealing DNA repair
Intracellular oxidative stress in cells transformed by the BCR-ABL oncogene is associated with increased DNA double-strand breaks. Imprecise repair of these breaks can result in the accumulation of mutations, leading to therapy-related drug resistance and disease progression. Using several BCR-ABL m...
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society of Hematology
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2738569/ https://ncbi.nlm.nih.gov/pubmed/19571320 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-07-172148 |
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