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The Concerted Action of Msh2 and UNG Stimulates Somatic Hypermutation at A · T Base Pairs
Mismatch repair plays an essential role in reducing the cellular mutation load. Paradoxically, proteins in this pathway produce A·T mutations during the somatic hypermutation of immunoglobulin genes. Although recent evidence implicates the translesional DNA polymerase η in producing these mutations,...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Microbiology (ASM)
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2738296/ https://ncbi.nlm.nih.gov/pubmed/19596785 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00647-09 |
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