Anti-Human Immunodeficiency Virus Activity, Cross-Resistance, Cytotoxicity, and Intracellular Pharmacology of the 3′-Azido-2′,3′-Dideoxypurine Nucleosides

Although the approved nucleoside reverse transcriptase (RT) inhibitors (NRTI) are integral components of therapy for human immunodeficiency virus type 1 (HIV-1) infection, they can have significant limitations, including the selection of NRTI-resistant HIV-1 and cellular toxicity. Accordingly, there...

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Main Authors: Sluis-Cremer, Nicolas, Koontz, Dianna, Bassit, Leda, Hernandez-Santiago, Brenda I., Detorio, Mervi, Rapp, Kim L., Amblard, Franck, Bondada, Lavanya, Grier, Jason, Coats, Steven J., Schinazi, Raymond F., Mellors, John W.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2009
Assuntos:
Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2737880/
https://ncbi.nlm.nih.gov/pubmed/19596885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00392-09
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