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Dual Ablation of Grb10 and Grb14 in Mice Reveals Their Combined Role in Regulation of Insulin Signaling and Glucose Homeostasis

Growth factor receptor bound (Grb)10 and Grb14 are closely related adaptor proteins that bind directly to the insulin receptor (IR) and regulate insulin-induced IR tyrosine phosphorylation and signaling to IRS-1 and Akt. Grb10- and Grb14-deficient mice both exhibit improved whole-body glucose homeos...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Holt, Lowenna J., Lyons, Ruth J., Ryan, Ashleigh S., Beale, Susan M., Ward, Andrew, Cooney, Gregory J., Daly, Roger J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Endocrine Society 2009
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2737556/
https://ncbi.nlm.nih.gov/pubmed/19541746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2008-0386
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