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Mice with a Disruption of the Imprinted Grb10 Gene Exhibit Altered Body Composition, Glucose Homeostasis, and Insulin Signaling during Postnatal Life

The Grb10 adapter protein is capable of interacting with a variety of receptor tyrosine kinases, including, notably, the insulin receptor. Biochemical and cell culture experiments have indicated that Grb10 might act as an inhibitor of insulin signaling. We have used mice with a disruption of the Grb...

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Detalhes bibliográficos
Main Authors: Smith, Florentia M., Holt, Lowenna J., Garfield, Alastair S., Charalambous, Marika, Koumanov, Francoise, Perry, Mark, Bazzani, Reto, Sheardown, Steven A., Hegarty, Bronwyn D., Lyons, Ruth J., Cooney, Gregory J., Daly, Roger J., Ward, Andrew
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1952119/
https://ncbi.nlm.nih.gov/pubmed/17562854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.02087-06
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