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Disruption of the imprinted Grb10 gene leads to disproportionate overgrowth by an Igf2-independent mechanism
To investigate the function of the Grb10 adapter protein, we have generated mice in which the Grb10 gene was disrupted by a gene-trap insertion. Our experiments confirm that Grb10 is subject to genomic imprinting with the majority of Grb10 expression arising from the maternally inherited allele. Con...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2003
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC166222/ https://ncbi.nlm.nih.gov/pubmed/12829789 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1532175100 |
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