Structural Basis for Inhibition of the Insulin Receptor by the Adaptor Protein Grb14

Grb14, a member of the Grb7 adaptor protein family, possesses a pleckstrin homology (PH) domain, a C-terminal Src homology-2 (SH2) domain, and an intervening stretch of ~45 residues known as the BPS region, which is unique to this adaptor family. Previous studies have demonstrated that Grb14 is a ti...

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Bibliographic Details
Published in:Mol Cell
Main Authors: Depetris, Rafael S., Hu, Junjie, Gimpelevich, Ilana, Holt, Lowenna J., Daly, Roger J., Hubbard, Stevan R.
Format: Artigo
Language:Inglês
Published: 2005
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4526137/
https://ncbi.nlm.nih.gov/pubmed/16246733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2005.09.001
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