Molecular Determinants of Grb14-Mediated Inhibition of Insulin Signaling

Grb14 belongs to the Grb7 family of molecular adapters and was identified as an inhibitor of insulin signaling. Grb14 binds to activated insulin receptors (IR) and inhibits their catalytic activity. To gain more insight into the Grb14 molecular mechanism of action, we generated various mutants and s...

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Bibliografiske detaljer
Udgivet i:Mol Endocrinol
Main Authors: Goenaga, Diana, Hampe, Cornelia, Carré, Nadège, Cailliau, Katia, Browaeys-Poly, Edith, Perdereau, Dominique, Holt, Lowenna J., Daly, Roger J., Girard, Jean, Broutin, Isabelle, Issad, Tarik, Burnol, Anne-Françoise
Format: Artigo
Sprog:Inglês
Udgivet: Endocrine Society 2009
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5419176/
https://ncbi.nlm.nih.gov/pubmed/19359342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2008-0360
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