The Adapter Protein ZIP Binds Grb14 and Regulates Its Inhibitory Action on Insulin Signaling by Recruiting Protein Kinase Cζ

Grb14 is a member of the Grb7 family of adapters and acts as a negative regulator of insulin-mediated signaling. Here we found that the protein kinase Cζ (PKCζ) interacting protein, ZIP, interacted with Grb14. Coimmunoprecipitation experiments demonstrated that ZIP bound to both Grb14 and PKCζ, ther...

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Autors principals: Cariou, Bertrand, Perdereau, Dominique, Cailliau, Katia, Browaeys-Poly, Edith, Béréziat, Véronique, Vasseur-Cognet, Mireille, Girard, Jean, Burnol, Anne-Françoise
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2002
Matèries:
Cell Growth and Development
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC139806/
https://ncbi.nlm.nih.gov/pubmed/12242277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.20.6959-6970.2002
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