RasGAP Shields Akt from Deactivating Phosphatases in Fibroblast Growth Factor Signaling but Loses This Ability Once Cleaved by Caspase-3

Fibroblast growth factor receptors (FGFRs) are involved in proliferative and differentiation physiological responses. Deregulation of FGFR-mediated signaling involving the Ras/PI3K/Akt and the Ras/Raf/ERK MAPK pathways is causally involved in the development of several cancers. The caspase-3/p120 Ra...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Cailliau, Katia, Lescuyer, Arlette, Burnol, Anne-Françoise, Cuesta-Marbán, Álvaro, Widmann, Christian, Browaeys-Poly, Edith
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4528130/
https://ncbi.nlm.nih.gov/pubmed/26109071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.644633
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