A WXW Motif Is Required for the Anticancer Activity of the TAT-RasGAP(317–326) Peptide

TAT-RasGAP(317–326), a cell-permeable 10-amino acid-long peptide derived from the N2 fragment of p120 Ras GTPase-activating protein (RasGAP), sensitizes tumor cells to apoptosis induced by various anticancer therapies. This RasGAP-derived peptide, by targeting the deleted in liver cancer-1 (DLC1) tu...

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Detalhes bibliográficos
Main Authors: Barras, David, Chevalier, Nadja, Zoete, Vincent, Dempsey, Rosemary, Lapouge, Karine, Olayioye, Monilola A., Michielin, Olivier, Widmann, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4156047/
https://ncbi.nlm.nih.gov/pubmed/25008324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.576272
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