TAT-RasGAP(317-326) kills cells by targeting inner-leaflet–enriched phospholipids

TAT-RasGAP(317–326) is a cell-penetrating peptide-based construct with anticancer and antimicrobial activities. This peptide kills a subset of cancer cells in a manner that does not involve known programmed cell death pathways. Here we have elucidated the mode of action allowing TAT-RasGAP(317–326)...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Serulla, Marc, Ichim, Gabriel, Stojceski, Filip, Grasso, Gianvito, Afonin, Sergii, Heulot, Mathieu, Schober, Tim, Roth, Robyn, Godefroy, Cédric, Milhiet, Pierre-Emmanuel, Das, Kushal, García-Sáez, Ana J., Danani, Andrea, Widmann, Christian
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2020
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7749316/
https://ncbi.nlm.nih.gov/pubmed/33257567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2014108117
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