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Sex, Age and Regional Differences in L-Type Calcium Current are important determinants of arrhythmia phenotype in Rabbit Hearts with drug induced Long QT type 2

In congenital and acquired long QT type 2 (LQT2), women are more vulnerable than men to Torsade de Pointes (TdP) but in pre-pubertal rabbits (and children), the arrhythmia phenotype is reversed; yet females still have longer action potential durations (APDs) than males. Thus, sex-differences in K(+)...

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Autors principals: Sims, Carl, Reisenweber, Steven, Viswanathan, Prakash C., Choi, Bum-Rak, Walker, William, Salama, Guy
Format: Artigo
Idioma:Inglês
Publicat: 2008
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2737508/
https://ncbi.nlm.nih.gov/pubmed/18436794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.108.173740
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