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Asymmetrically designed siRNAs and shRNAs enhance the strand specificity and efficacy in RNAi
RNAi can mediate allele-specific silencing, and offers an attractive approach for treatment of human diseases caused by dominant, gain-of-function gene mutations. However, allele-specific silencing requires that the RNAi target the mutated region of the mRNA, limiting the choices of the target seque...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Library Publishing Media
2007
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2737237/ https://ncbi.nlm.nih.gov/pubmed/19771234 |
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