Asymmetrically designed siRNAs and shRNAs enhance the strand specificity and efficacy in RNAi

RNAi can mediate allele-specific silencing, and offers an attractive approach for treatment of human diseases caused by dominant, gain-of-function gene mutations. However, allele-specific silencing requires that the RNAi target the mutated region of the mRNA, limiting the choices of the target seque...

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Detaylı Bibliyografya
Asıl Yazarlar: Ding, Hongliu, Liao, Guoqing, Wang, Hongyan, Zhou, Yejin
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Library Publishing Media 2007
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2737237/
https://ncbi.nlm.nih.gov/pubmed/19771234
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