Asymmetrically designed siRNAs and shRNAs enhance the strand specificity and efficacy in RNAi

RNAi can mediate allele-specific silencing, and offers an attractive approach for treatment of human diseases caused by dominant, gain-of-function gene mutations. However, allele-specific silencing requires that the RNAi target the mutated region of the mRNA, limiting the choices of the target seque...

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Библиографические подробности
Главные авторы: Ding, Hongliu, Liao, Guoqing, Wang, Hongyan, Zhou, Yejin
Формат: Artigo
Язык:Inglês
Опубликовано: Library Publishing Media 2007
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2737237/
https://ncbi.nlm.nih.gov/pubmed/19771234
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