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Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs
Canonical microRNAs (miRNAs) require two processing steps: the first by the Microprocessor, a complex of DGCR8 and Drosha, and the second by a complex of TRBP and Dicer. dgcr8Δ/Δ mouse embryonic stem cells (mESCs) have less severe phenotypes than dicer1Δ/Δ mESCs, suggesting a physiological role for...
Tallennettuna:
| Päätekijät: | , , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Cold Spring Harbor Laboratory Press
2008
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2569885/ https://ncbi.nlm.nih.gov/pubmed/18923076 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1705308 |
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