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Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs

Canonical microRNAs (miRNAs) require two processing steps: the first by the Microprocessor, a complex of DGCR8 and Drosha, and the second by a complex of TRBP and Dicer. dgcr8Δ/Δ mouse embryonic stem cells (mESCs) have less severe phenotypes than dicer1Δ/Δ mESCs, suggesting a physiological role for...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Babiarz, Joshua E., Ruby, J. Graham, Wang, Yangming, Bartel, David P., Blelloch, Robert
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Cold Spring Harbor Laboratory Press 2008
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2569885/
https://ncbi.nlm.nih.gov/pubmed/18923076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1705308
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