Basal Subtype and MAPK/ERK Kinase (MEK)-Phosphoinositide 3-Kinase Feedback Signaling Determine Susceptibility of Breast Cancer Cells to MEK Inhibition

Specific inhibitors of mitogen-activated protein kinase/extra-cellular signal-regulated kinase (ERK) kinase (MEK) have been developed that efficiently inhibit the oncogenic RAF-MEK-ERK pathway. We used a systems-based approach to identify breast cancer subtypes particularly susceptible to MEK inhibi...

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Hlavní autoři: Mirzoeva, Olga K., Das, Debopriya, Heiser, Laura M., Bhattacharya, Sanchita, Siwak, Doris, Gendelman, Rina, Bayani, Nora, Wang, Nicholas J., Neve, Richard M., Guan, Yinghui, Hu, Zhi, Knight, Zachary, Feiler, Heidi S., Gascard, Philippe, Parvin, Bahram, Spellman, Paul T., Shokat, Kevan M., Wyrobek, Andrew J., Bissell, Mina J., McCormick, Frank, Kuo, Wen-Lin, Mills, Gordon B., Gray, Joe W., Korn, W. Michael
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2737189/
https://ncbi.nlm.nih.gov/pubmed/19147570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-3389
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