Basal Subtype and MAPK/ERK Kinase (MEK)-Phosphoinositide 3-Kinase Feedback Signaling Determine Susceptibility of Breast Cancer Cells to MEK Inhibition

Specific inhibitors of mitogen-activated protein kinase/extra-cellular signal-regulated kinase (ERK) kinase (MEK) have been developed that efficiently inhibit the oncogenic RAF-MEK-ERK pathway. We used a systems-based approach to identify breast cancer subtypes particularly susceptible to MEK inhibi...

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Detalhes bibliográficos
Main Authors: Mirzoeva, Olga K., Das, Debopriya, Heiser, Laura M., Bhattacharya, Sanchita, Siwak, Doris, Gendelman, Rina, Bayani, Nora, Wang, Nicholas J., Neve, Richard M., Guan, Yinghui, Hu, Zhi, Knight, Zachary, Feiler, Heidi S., Gascard, Philippe, Parvin, Bahram, Spellman, Paul T., Shokat, Kevan M., Wyrobek, Andrew J., Bissell, Mina J., McCormick, Frank, Kuo, Wen-Lin, Mills, Gordon B., Gray, Joe W., Korn, W. Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2737189/
https://ncbi.nlm.nih.gov/pubmed/19147570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-3389
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